Altered gene expression in schizophrenia: findings from transcriptional signatures in fibroblasts and blood.

ABSTRACT:

Background

Whole-genome expression studies in the peripheral tissues of patients affected by schizophrenia (SCZ) can provide new insight into the molecular basis of the disorder and innovative biomarkers that may be of great utility in clinical practice. Recent evidence suggests that skin fibroblasts could represent a non-neural peripheral model useful for investigating molecular alterations in psychiatric disorders.

Methods

A microarray expression study was conducted comparing skin fibroblast transcriptomic profiles from 20 SCZ patients and 20 controls. All genes strongly differentially expressed were validated by real-time quantitative PCR (RT-qPCR) in fibroblasts and analyzed in a sample of peripheral blood cell (PBC) RNA from patients (n = 25) and controls (n = 22). To e

SUBMITTER: Cattane N 

PROVIDER: S-EPMC4319917 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature