Do variants associated with susceptibility to pancreatic cancer and type 2 diabetes reciprocally affect risk?

ABSTRACT:

Objectives

Although type 2 diabetes mellitus is a known risk factor for pancreatic cancer, the existence of shared genetic susceptibility is largely unknown. We evaluated whether any reported genetic risk variants of either disease found by genome-wide association studies reciprocally confer susceptibility.

Methods

Data that were generated in previous genome-wide association studies (GENEVA Type 2 Diabetes; PanScan) were obtained through the National Institutes of Health database of Genotypes and Phenotypes (dbGaP). Using the PanScan datasets, we tested for association of 38 variants within 37 genomic regions known to be susceptibility factors for type 2 diabetes. We further examined whether type 2 diabetes variants predispose to pancreatic cancer risk stratified by diabetes

SUBMITTER: Wu L 

PROVIDER: S-EPMC4319943 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature