EIF4EBP1 overexpression is associated with poor survival and disease progression in patients with hepatocellular carcinoma.

ABSTRACT:

Objective

EIF4EBP1 acts as a crucial effector in mTOR signaling pathway. Studies have suggested that EIF4EBP1 plays a critical role in carcinogenesis. However, the clinical significance and biological role of EIF4EBP1 in hepatocellular carcinoma (HCC) have not been elucidated. Therefore, we aimed to investigate the clinical significance of EIF4EBP1 in HCC.

Methods

Total 128 cases of HCCs were included in this study. EIF4EBP1 expression in HCC tissues was detected by qRT-PCR, Western blot and immunohistochemistry, respectively. Then the relationships between EIF4EBP1 expression and clinical features as well as survival were analyzed.

Results

The expression level of EIF4EBP1 mRNA is significantly higher in 60% (24/40) of fresh HCC tissues than that in the matched adjace

SUBMITTER: Cha YL 

PROVIDER: S-EPMC4319970 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature