No association between Apoε4 alleles, HIV infection, age, neuropsychological outcome, or death.

ABSTRACT: The ε4 allele of the apolipoprotein E (ApoE) gene may have important interactions with physical health and cognitive function among individuals with HIV disease. The purpose of this study is to examine the relationships between ε4, HIV disease, age, neuropsychological impairment, and death in a large, well-characterized study sample. A total of 2846 men participating in the Multicenter AIDS Cohort Study had ApoE genotyping and neuropsychological test data available for analysis. We found a significant association between HIV infection and time to death (from any cause), as well as older age, race, and education. But, ApoE status was not significantly associated with time to death. Similarly, we found a significant association between HIV infection and time to incident cognitive impairment,

SUBMITTER: Becker JT 

PROVIDER: S-EPMC4319994 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature