Microvascular lesions by estrogen-induced ID3: its implications in cerebral and cardiorenal vascular disease.

ABSTRACT: Severe symptoms of cerebral and cardiorenal vascular diseases can be triggered when cerebral, coronary, or glomerular arterioles grow inappropriately as a result of abnormal cell proliferation. The risk factor(s) and molecular mechanisms responsible for microvascular lesion formation are largely unknown. Although controversial, both animal and epidemiological studies have shown that estrogen increases the risk of stroke which may be due to microvascular lesions. Since microvascular diseases are characterized by excessive vessel growth, it is plausible that estrogen-induced neovascularization contributes to the growth of microvascular lesions. We present evidence for how ID3 overexpression in endothelial cells contributes to the development of an estrogen-induced neovascular phenotype with

SUBMITTER: Das JK 

PROVIDER: S-EPMC4320014 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature