Analysis of gene-gene interactions among common variants in candidate cardiovascular genes in coronary artery disease.

ABSTRACT:

Objective

Only a small fraction of coronary artery disease (CAD) heritability has been explained by common variants identified to date. Interactions between genes of importance to cardiovascular regulation may account for some of the missing heritability of CAD. This study aimed to investigate the role of gene-gene interactions in common variants in candidate cardiovascular genes in CAD.

Approach and results

2,101 patients with CAD from the British Heart Foundation Family Heart Study and 2,426 CAD-free controls were included in the discovery cohort. All subjects were genotyped with the Illumina HumanCVD BeadChip enriched for genes and pathways relevant to the cardiovascular system and disease. The primary analysis in the discovery cohort examined pairwise interactions among

SUBMITTER: Musameh MD 

PROVIDER: S-EPMC4320092 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature