Integrative analysis of micro-RNA, gene expression, and survival of glioblastoma multiforme.

ABSTRACT: Glioblastoma multiforme (GBM), the most common type of malignant brain tumor, is highly fatal. Limited understanding of its rapid progression necessitates additional approaches that integrate what is known about the genomics of this cancer. Using a discovery set (n = 348) and a validation set (n = 174) of GBM patients, we performed genome-wide analyses that integrated mRNA and micro-RNA expression data from GBM as well as associated survival information, assessing coordinated variability in each as this reflects their known mechanistic functions. Cox proportional hazards models were used for the survival analyses, and nonparametric permutation tests were performed for the micro-RNAs to investigate the association between the number of associated genes and its prognostication. We also utili

SUBMITTER: Huang YT 

PROVIDER: S-EPMC4320123 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature