The CHEK2 1100delC allelic variant is not present in familial and sporadic breast cancer cases from Moroccan population.

ABSTRACT:

Purpose

The cell-cycle checkpoint kinase 2 (CHEK2) is an important signal transducer of cellular responses to DNA damage, whose defects has been associated with increased risk for breast cancer. The CHEK2 1100delC mutation has been reported to confer a twofold increased risk of breast cancer among carriers. The frequency of the mutation varies among populations. The highest frequency has been described in Northern and Eastern European countries. However, the 1100delC mutation has been investigated in different case-control studies and none in Moroccan population. The aim of this study was to evaluate the prevalence of this variant and determine its contribution to the development of breast cancer in sporadic cases and also in members of breast cancer families who tested negative or

SUBMITTER: Marouf C 

PROVIDER: S-EPMC4320163 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature