Huachansu injection inhibits metastasis of pancreatic cancer in mice model of human tumor xenograft.

ABSTRACT:

Background

Huachansu injection (HCS) is a water-soluble preparation made from Bufo gargarizans's skin, which has been widely used in clinics for tumor therapy in China. Though the anti-cancer activity of HCS has been verified through studies in vitro and in vivo, there is little research about its potential anti-metastasis effect. The primary objective of this study was to assess the effects of HCS on both the invasion of pancreatic cancer cells in vitro and on the progression of liver metastasis in vivo in this study.

Methods

HCS anti-metastasis potential was accessed using both assay of Cell viability and invasion in vitro, and then further Establishing xenograft model in nude mice. In the cell-based assay, mRNA and protein expression of MMP-2, MMP-9 and VEGF was detected

SUBMITTER: Yin JH 

PROVIDER: S-EPMC4320457 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature