A hyper-dynamic nature of bivalent promoter states underlies coordinated developmental gene expression modules.

ABSTRACT:

Background

Chromatin remodeling is crucial for proper programing of developmental gene expression. Recent work provides a dynamic view of post-translational histone modifications during differentiation; however there is little insight on the evolution of combinatorial genome-wide patterns of chromatin marks, excluding an essential aspect of developmental gene regulation.

Results

We report here a 15-chromatin state Hidden Markov Model which describes changes in chromatin signatures in relation to transcription profiles during differentiation of human pre-adipocytes into adipocytes. We identify nineteen modules of gene expression reflecting multiple waves of transcriptional up- and down-regulation which characterize adipogenic differentiation. From our model, we developed chro

SUBMITTER: Shah A 

PROVIDER: S-EPMC4320513 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature