Association of ERCC1 rs3212986 & ERCC2 rs13181 polymorphisms with the risk of glioma.

ABSTRACT:

Objective

: Several previous studies have reported the role variant of ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms in the risk of glioma, but the results of these studies are inconsistent. Therefore, we aimed to conduct a meta-analysis to investigate the role of ERCC1 rs3212986 and ERCC2 rs13181 on the risk of glioma.

Methods

A comprehensive research was conducted through the databases of Pubmed, EMBASE and the China National Knowledge Infrastructure (CNKI) platforms until June 1, 2014, including 14 eligible case-control studies.

Results

Our meta-analysis found that ERCC1 rs3212986 AA genotype was significantly associated with increased risk of glioma compared with CC genotype, and the pooled OR (95%CI) was 1.29(1.07-1.55). By subgroup analysis, ERCC1 rs3212986 AA

SUBMITTER: Cui QK 

PROVIDER: S-EPMC4320740 | biostudies-literature | 2014 Nov-Dec

REPOSITORIES: biostudies-literature