Evaluating the feasibility of performing window of opportunity trials in breast cancer.

ABSTRACT:

Background

The waiting period to surgery represents a valuable "window of opportunity" to evaluate novel therapeutic strategies. Interventional studies performed during this period require significant multidisciplinary collaboration to overcome logistical hurdles. We undertook a one-year prospective window of opportunity study to assess feasibility.

Methods

Eligible newly diagnosed postmenopausal, estrogen receptor positive breast cancer patients awaiting primary surgery received anastrozole daily until surgery. Feasibility was assessed by (a) the proportion of patients who consented and (b) completed the study. Comparison of pre- and poststudy Ki67 labelling index and cleaved caspase 3 scores (CC3) was performed.

Results

22/131 (16.8%) patients were confirmed eligibl

SUBMITTER: Arnaout A 

PROVIDER: S-EPMC4320871 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature