Preoperative dietary restriction reduces intimal hyperplasia and protects from ischemia-reperfusion injury.

ABSTRACT:

Objective

Whereas chronic overnutrition is a risk factor for surgical complications, long-term dietary restriction (reduced food intake without malnutrition) protects in preclinical models of surgical stress. Building on the emerging concept that acute preoperative dietary perturbations can affect the body's response to surgical stress, we hypothesized that short-term high-fat diet (HFD) feeding before surgery is detrimental, whereas short-term nutrient/energy restriction before surgery can reverse negative outcomes. We tested this hypothesis in two distinct murine models of vascular surgical injury, ischemia-reperfusion (IR) and intimal hyperplasia (IH).

Methods

Short-term overnutrition was achieved by feeding mice a HFD consisting of 60% calories from fat for 2 weeks. Shor

SUBMITTER: Mauro CR 

PROVIDER: S-EPMC4320991 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature