Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.

ABSTRACT:

Background

The strong observational association between total homocysteine (tHcy) concentrations and risk of coronary artery disease (CAD) and the null associations in the homocysteine-lowering trials have prompted the need to identify genetic variants associated with homocysteine concentrations and risk of CAD.

Objective

We tested whether common genetic polymorphisms associated with variation in tHcy are also associated with CAD.

Design

We conducted a meta-analysis of genome-wide association studies (GWAS) on tHcy concentrations in 44,147 individuals of European descent. Polymorphisms associated with tHcy (P < 10(⁻⁸) were tested for association with CAD in 31,400 cases and 92,927 controls.

Results

Common variants at 13 loci, explaining 5.9% of the variation in

SUBMITTER: van Meurs JB 

PROVIDER: S-EPMC4321227 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature