Jagged-Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype.

ABSTRACT: Notch signaling pathway mediates cell-fate determination during embryonic development, wound healing, and tumorigenesis. This pathway is activated when the ligand Delta or the ligand Jagged of one cell interacts with the Notch receptor of its neighboring cell, releasing the Notch Intracellular Domain (NICD) that activates many downstream target genes. NICD affects ligand production asymmetrically--it represses Delta, but activates Jagged. Although the dynamical role of Notch-Jagged signaling remains elusive, it is widely recognized that Notch-Delta signaling behaves as an intercellular toggle switch, giving rise to two distinct fates that neighboring cells adopt--Sender (high ligand, low receptor) and Receiver (low ligand, high receptor). Here, we devise a specific theoretical framework th

SUBMITTER: Boareto M 

PROVIDER: S-EPMC4321269 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature