Enhancer-bound LDB1 regulates a corticotrope promoter-pausing repression program.

ABSTRACT: Substantial evidence supports the hypothesis that enhancers are critical regulators of cell-type determination, orchestrating both positive and negative transcriptional programs; however, the basic mechanisms by which enhancers orchestrate interactions with cognate promoters during activation and repression events remain incompletely understood. Here we report the required actions of LIM domain-binding protein 1 (LDB1)/cofactor of LIM homeodomain protein 2/nuclear LIM interactor, interacting with the enhancer-binding protein achaete-scute complex homolog 1, to mediate looping to target gene promoters and target gene regulation in corticotrope cells. LDB1-mediated enhancer:promoter looping appears to be required for both activation and repression of these target genes. Although LDB1-depende

SUBMITTER: Zhang F 

PROVIDER: S-EPMC4321301 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature