Cancer Systems Biology: a peek into the future of patient care?

ABSTRACT: Traditionally, scientific research has focused on studying individual events, such as single mutations, gene function, or the effect that mutating one protein has on a biological phenotype. A range of technologies is beginning to provide information that will enable a holistic view of how genomic and epigenetic aberrations in cancer cells can alter the homeostasis of signalling networks within these cells, between cancer cells and the local microenvironment, and at the organ and organism level. This process, termed Systems Biology, needs to be integrated with an iterative approach wherein hypotheses and predictions that arise from modelling are refined and constrained by experimental evaluation. Systems biology approaches will be vital for developing and implementing effective strategies t

SUBMITTER: Werner HM 

PROVIDER: S-EPMC4321721 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature