Interleukin-6, C-reactive protein, and tumor necrosis factor-alpha as predictors of mortality in frail, community-living elderly individuals.

ABSTRACT:

Unlabelled

To investigate whether interleukin-6 (IL-6), C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) protein levels predict all-cause mortality in older persons living in the community.

Design

Prospective cohort study.

Setting

Data were from the Aging and Longevity Study in the Sirente Geographic Area, a prospective cohort study.

Participants

Individuals aged 80 and older living in an Italian mountain community (N = 362).

Measurements

Participants were classified according to the median value of the three inflammation markers (IL-6, 2.08 pg/mL; TNF-α, 1.43 pg/mL; CRP, 3.08 mg/L). A composite summary score of inflammation was also created. The main outcome was risk of death after 4 years of follow-up.

Results

One hundred fifty d

SUBMITTER: Giovannini S 

PROVIDER: S-EPMC4321727 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature