Racial differences in CT phenotypes in COPD.

ABSTRACT:

Background

Whether African Americans (AA) are more susceptible to COPD than non-Hispanic Whites (NHW) and whether racial differences in disease phenotype exist is controversial. The objective is to determine racial differences in the extent of emphysema and airway remodeling in COPD.

Methods

First, 2,500 subjects enrolled in the COPDGene study were used to evaluate racial differences in quantitative CT (QCT) parameters of% emphysema, air trapping and airway wall thickness. Independent variables studied included race, age, gender, education, BMI, pack-years, smoking status, age at smoking initiation, asthma, previous work in dusty job, CT scanner and center of recruitment.

Results

Of the 1,063 subjects with GOLD Stage II-IV COPD, 200 self-reported as AA. AAs had a lowe

SUBMITTER: Hansel NN 

PROVIDER: S-EPMC4321889 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature