Clinical and histologic features of azithromycin-induced liver injury.

ABSTRACT:

Background & aims

Rare cases of azithromycin-induced hepatotoxicity have been reported, with variable clinical and histologic features. We characterized clinical features and outcomes of azithromycin-induced liver injury.

Methods

We identified patients with azithromycin-induced liver injury from the Drug-Induced Liver Injury Network Prospective Study who had causality scores of definite, highly likely, or probable. Demographic, clinical, and laboratory data and 6-month outcomes were examined.

Results

Eighteen patients (72% female; mean age, 37 y) had causality scores of definite (n = 1), highly likely (n = 9), or probable (n = 8). Common presenting symptoms were jaundice, abdominal pain, nausea, and/or pruritus. For 16 patients, abnormal results from liver tests were

SUBMITTER: Martinez MA 

PROVIDER: S-EPMC4321982 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature