Targeting axonal protein synthesis in neuroregeneration and degeneration.

ABSTRACT: Localized protein synthesis is a mechanism by which morphologically polarized cells react in a spatially confined and temporally acute manner to changes in their environment. During the development of the nervous system intra-axonal protein synthesis is crucial for the establishment of neuronal connections. In contrast, mature axons have long been considered as translationally inactive but upon nerve injury or under neurodegenerative conditions specific subsets of mRNAs are recruited into axons and locally translated. Intra-axonally synthesized proteins can have pathogenic or restorative and regenerative functions, and thus targeting the axonal translatome might have therapeutic value, for example in the treatment of spinal cord injury or Alzheimer's disease. In the case of Alzheimer's dis

SUBMITTER: Baleriola J 

PROVIDER: S-EPMC4322063 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature