Association of ADAM33 gene polymorphisms with allergic asthma.

ABSTRACT:

Objectives

Asthma results from the interaction between genetic and environmental factors. ADAM33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness.

Materials and methods

This is a case-control study, where four SNPs S1 (rs3918396), T1 (rs2280091), T2 (rs2280090), V4 (rs2787094) of ADAM33 gene have been assessed in patients with allergic asthma and normal controls (95 patients and 86 normal). Blood samples of these participants have been genotyped by PCR and the RFLP method.

Results

There was no association between asthmatic patients and polymorphisms of alleles, genotypes and haplotypes of the ADAM33 gene. When categorizing the asthmatic patients in severe, moderate and mild groups, associations in the subcategories of asthmatic patient

SUBMITTER: Karimi MR 

PROVIDER: S-EPMC4322157 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature