Utility of early screening magnetic resonance imaging for extensive hip osteonecrosis in pediatric patients treated with glucocorticoids.

ABSTRACT:

Purpose

Hip osteonecrosis frequently complicates treatment with glucocorticoids. When extensive (affecting ≥ 30% of the epiphyseal surface), 80% of joints collapse within 2 years, so interventions are needed to prevent this outcome.

Patients and methods

This prospective cohort magnetic resonance imaging (MRI) screening study included all consecutive children treated for acute lymphoblastic leukemia on a single protocol. Hip MRI was performed at 6.5 and 9 months from diagnosis (early screening) and at completion of chemotherapy (final evaluation) to determine whether screening could identify extensive hip osteonecrosis before symptom development.

Results

Of 498 patients, 462 underwent screening MRI. Extensive asymptomatic osteonecrosis was identified by early screening

SUBMITTER: Kaste SC 

PROVIDER: S-EPMC4322260 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature