Meta-analyses on prevalence of selected Parkinson's nonmotor symptoms before and after diagnosis.

ABSTRACT:

Background

Nonmotor symptoms are common among patients with Parkinson's disease (PD) and some may precede disease diagnosis.

Methods

We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis, using random-effect models. We searched PubMed (1965 through October/November 2012) for the following symptoms: hyposmia, constipation, rapid eye movement sleep behavior disorder, excessive daytime sleepiness, depression, and anxiety. Eligible studies were publications in English with original data on one or more of these symptoms.

Results

The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria, mostly (n = 320) on symptoms after PD diagnosis. For all symptoms, the prevalence was substantially high

SUBMITTER: Chen H 

PROVIDER: S-EPMC4322463 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature