Redox and nitric oxide-mediated regulation of sensory neuron ion channel function.

ABSTRACT:

Significance

Reactive oxygen and nitrogen species (ROS and RNS, respectively) can intimately control neuronal excitability and synaptic strength by regulating the function of many ion channels. In peripheral sensory neurons, such regulation contributes towards the control of somatosensory processing; therefore, understanding the mechanisms of such regulation is necessary for the development of new therapeutic strategies and for the treatment of sensory dysfunctions, such as chronic pain.

Recent advances

Tremendous progress in deciphering nitric oxide (NO) and ROS signaling in the nervous system has been made in recent decades. This includes the recognition of these molecules as important second messengers and the elucidation of their metabolic pathways and cellular targets.

SUBMITTER: Gamper N 

PROVIDER: S-EPMC4323017 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature