Prognostic value of components of body composition in patients treated with targeted therapy for advanced renal cell carcinoma: a retrospective case series.

ABSTRACT:

Background

To evaluate the association between various components of body composition and overall survival of patients treated with targeted therapies for advanced renal cell carcinoma.

Methods

This retrospective study included 124 Chinese patients with advanced renal cell carcinoma who had been treated with targeted therapy from 2008 to 2012 at Fudan University Cancer Center. The L3 plane from a computed tomography scan was analyzed. Area and density were recorded as quantitative and quality measures. Univariate and multivariate Cox proportion hazard regression models were constructed to calculate the crude and adjusted hazard ratio (HR) of various components of body composition for overall survival. X-tile software was used to search for optimal cutoffs for male and female

SUBMITTER: Gu W 

PROVIDER: S-EPMC4323238 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature