Characterization and comparison of bacterial communities in benign vocal fold lesions.

ABSTRACT:

Background

Benign vocal fold lesions, including cysts, nodules, polyps, and Reinke's edema, are common causes of hoarseness and subsequent voice disorders. Given the prevalence of these lesions, disease etiology and pathophysiology remain unclear and their microbiota has not been studied to date secondary to the paucity of available biopsies for investigation. We sought to characterize and compare the bacterial communities in biopsies of cysts, nodules, polyps, and Reinke's edema collected from patients in Germany and Wisconsin. These samples were then compared to the communities found in healthy saliva and throat samples from the Human Microbiome Project (HMP).

Results

454 pyrosequencing of the V3-V5 regions of the 16S rRNA gene revealed five phyla that explained most of th

SUBMITTER: Hanshew AS 

PROVIDER: S-EPMC4323261 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature