Atypical frontal-striatal-thalamic circuit white matter development in pediatric obsessive-compulsive disorder.

ABSTRACT:

Objective

Atypical development of frontal-striatal-thalamic circuitry (FSTC) has been hypothesized to underlie the early course of obsessive-compulsive disorder (OCD); however, the development of FSTC white matter tracts remains to be studied in young patients.

Method

To address this gap, we scanned 36 patients with pediatric OCD compared to 27 healthy controls, aged 8 to 19 years, with diffusion tensor imaging (DTI) to measure fractional anisotropy (FA), an index of white matter coherence. Tract-based spatial statistics (TBSS) were used to test differential effects of age on FA, across the whole brain, in those with OCD compared to healthy youth, followed by analyses in a priori regions of interest (anterior corpus callosum, anterior cingulum bundle, and anterior limb of th

SUBMITTER: Fitzgerald KD 

PROVIDER: S-EPMC4323383 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature