Aberrant synaptic integration in adult lamina I projection neurons following neonatal tissue damage.

ABSTRACT: Mounting evidence suggests that neonatal tissue damage evokes alterations in spinal pain reflexes which persist into adulthood. However, less is known about potential concomitant effects on the transmission of nociceptive information to the brain, as the degree to which early injury modulates synaptic integration and membrane excitability in mature spinal projection neurons remains unclear. Here we demonstrate that neonatal surgical injury leads to a significant shift in the balance between synaptic excitation and inhibition onto identified lamina I projection neurons of the adult mouse spinal cord. The strength of direct primary afferent input to mature spino-parabrachial neurons was enhanced following neonatal tissue damage, whereas the efficacy of both GABAergic and glycinergic inhibiti

SUBMITTER: Li J 

PROVIDER: S-EPMC4323529 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature