Biochemical estimation of noncompliance with smoking of very low nicotine content cigarettes.

ABSTRACT:

Background

The reduction of the nicotine content of cigarettes to nonaddicting levels is a potential federal regulatory intervention to reduce the prevalence of cigarette smoking and related disease. Many clinical trials on the effects and safety of nicotine reduction are ongoing. An important methodologic concern is noncompliance with reduced nicotine content cigarettes in the context of freely available conventional cigarettes. We propose two approaches using biomarkers to estimate noncompliance in smokers of very low nicotine content (VLNC) cigarettes in a clinical trial.

Methods

Data from 50 subjects in a study of gradual nicotine reduction were analyzed. Using plasma cotinine concentrations measured at baseline and while smoking VLNC cigarettes, we compared within-subje

SUBMITTER: Benowitz NL 

PROVIDER: S-EPMC4323626 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature