Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance.

ABSTRACT: Current therapy for glioblastoma multiforme (GBM) is largely ineffective, with nearly universal tumor recurrence. The failure of current therapy is primarily due to the lack of approaches for the efficient delivery of therapeutics to diffuse tumors in the brain. In our prior study, we developed brain-penetrating nanoparticles that are capable of penetrating brain tissue and distribute over clinically relevant volumes when administered via convection-enhanced delivery (CED). We demonstrated that these particles are capable of efficient delivery of chemotherapeutics to diffuse tumors in the brain, indicating that they may serve as a groundbreaking approach for the treatment of GBM. In the original study, nanoparticles in the brain were imaged using positron emission tomography (PET). However

SUBMITTER: Strohbehn G 

PROVIDER: S-EPMC4323763 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature