Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice.

ABSTRACT:

Background

Antiphospholipid syndrome patients have antiphospholipid antibodies (aPLs) that promote thrombosis, and they have increased cardiovascular disease risk. Although the basis for the thrombosis has been well delineated, it is not known why antiphospholipid syndrome patients also have an increased prevalence of nonthrombotic vascular occlusion. The aims of this work were to determine if aPLs directly promote medial hypertrophy or neointima formation in mice and to identify the underlying mechanisms.

Methods and results

Medial hypertrophy and neointima formation invoked by carotid artery endothelial denudation were evaluated in mice administered normal human IgG or aPLs. While aPLs had no effect on medial hypertrophy, they caused exaggerated neointima development. This

SUBMITTER: Ulrich V 

PROVIDER: S-EPMC4323803 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature