Dataset Information

Renal handling of galectin-3 in the general population, chronic heart failure, and hemodialysis.

ABSTRACT:

Background

Galectin-3 is a biomarker for prognostication and risk stratification of patients with heart failure (HF). It has been suggested that renal function strongly relates to galectin-3 levels. We aimed to describe galectin-3 renal handling in HF.

Methods and results

In Sprague-Dawley rats, we infused galectin-3 and studied distribution and renal clearance. Furthermore, galectin-3 was measured in urine and plasma of healthy controls, HF patients and hemodialysis patients. To mimic the human situation, we measured galectin-3 before and after the artificial kidney. Infusion in rats resulted in a clear increase in plasma and urine galectin-3. Plasma galectin-3 in HF patients (n=101; mean age 64 years; 93% male) was significantly higher compared to control subjects (n=20; mean age 58 years; 75% male) (16.6 ng/mL versus 9.7 ng/mL, P<0.001), while urinary galectin-3 in HF patients was comparable (28.1 ng/mL versus 35.1 ng/mL, P=0.830). The calculated galectin-3 excretion rate was lower in HF patient (2.3 mL/min [1.5 to 3.4] versus 3.9 mL/min [2.3 to 6.4] in control subjects; P=0.005). This corresponded with a significantly lower fractional excretion of galectin-3 in HF patients (2.4% [1.7 to 3.7] versus 3.0% [1.9 to 5.5]; P=0.018). These differences, however, were no longer significant after correction for age, gender, diabetes, and smoking. HF patients who received diuretics (49%) showed significantly higher aldosterone and galectin-3 levels. Hemodialysis patients (n=105; mean age 63 years; 65% male), without urinary galectin-3 excretion, had strongly increased median plasma galectin-3 levels (70.6 ng/mL).

Conclusions

In this small cross-sectional study, we report that urine levels of galectin-3 are not increased in HF patients, despite substantially increased plasma galectin-3 levels. The impaired renal handling of galectin-3 in patients with HF may explain the described relation between renal function and galectin-3 and may account for the elevated plasma galectin-3 in HF.

SUBMITTER: Meijers WC

PROVIDER: S-EPMC4323807 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Publications

Renal handling of galectin-3 in the general population, chronic heart failure, and hemodialysis.

Meijers Wouter C WC van der Velde A Rogier AR Ruifrok Willem P WP Schroten Nicolas F NF Dokter Martin M MM Damman Kevin K Assa Solmaz S Franssen Casper F CF Gansevoort Ron T RT van Gilst Wiek H WH Silljé Herman H HH de Boer Rudolf A RA

Journal of the American Heart Association 20140918 5

<h4>Background</h4>Galectin-3 is a biomarker for prognostication and risk stratification of patients with heart failure (HF). It has been suggested that renal function strongly relates to galectin-3 levels. We aimed to describe galectin-3 renal handling in HF.<h4>Methods and results</h4>In Sprague-Dawley rats, we infused galectin-3 and studied distribution and renal clearance. Furthermore, galectin-3 was measured in urine and plasma of healthy controls, HF patients and hemodialysis patients. To ...[more]

PMID: 25237044

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Dataset Information

Renal handling of galectin-3 in the general population, chronic heart failure, and hemodialysis.

Background

Methods and results

Conclusions

Publications

Renal handling of galectin-3 in the general population, chronic heart failure, and hemodialysis.

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