Prognostic value of estimated functional capacity incremental to cardiac biomarkers in stable cardiac patients.

ABSTRACT:

Background

Few studies have investigated functional capacity self-assessment tools in either prediction of future major adverse cardiac outcomes beyond all-cause mortality or direct comparisons with clinically available biomarkers.

Methods and results

We estimated functional capacity using the Duke Activity Status Index (DASI) questionnaire in 8987 sequential stable patients without acute coronary syndrome who were undergoing elective diagnostic coronary angiography with 3-year follow-up of major adverse cardiac events (death, nonfatal myocardial infarction, or stroke). A low DASI score provided independent prediction of a 4.8-fold increase in future risk of incident major adverse cardiac events at 3 years (quartiles 1 versus 4 hazard ratio [95% CI] 4.76 [4.03 to 5.61], P<0.

SUBMITTER: Tang WH 

PROVIDER: S-EPMC4323823 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature