Decongestion strategies and renin-angiotensin-aldosterone system activation in acute heart failure.

ABSTRACT:

Objectives

The purpose of this study was to assess the relationship between biomarkers of renin-angiotensin-aldosterone system (RAAS) activation and decongestion strategies, worsening renal function, and clinical outcomes.

Background

High-dose diuretic therapy in patients with acute heart failure (AHF) is thought to activate the RAAS; and alternative decongestion strategies, such as ultrafiltration (UF), have been proposed to mitigate this RAAS activation.

Methods

This study analyzed 427 AHF patients enrolled in the DOSE-AHF (Diuretic Optimization Strategies in Acute Heart Failure) and CARRESS-HF (Cardiorenal Rescue Study in Acute Decompensated Heart Failure) trials. We assessed the relationship between 2 markers of RAAS activation (plasma renin activity [PRA] and ald

SUBMITTER: Mentz RJ 

PROVIDER: S-EPMC4324057 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature