Review of literature: genes related to postaxial polydactyly.

ABSTRACT:

Background

Postaxial polydactyly (PAP) is one of the commonest congenital malformations and usually is associated to several syndromes. There is no primary investigational strategy for PAP cases with single gene disorder in literature. PAP cases with single gene disorder can be classified according to common pathways and molecular basis. Molecular classification may help in diagnostic approach.

Materials and methods

All single gene disorders associated with PAP reported on PubMed and OMIM are analyzed and classified according to molecular basis.

Results

Majority of genes related to cilia structure and functions are associated with PAP, so we classified them as ciliopathies and non-ciliopathies groups. Genes related to Shh-Gli3 pathway was the commonest group in non-ci

SUBMITTER: Verma PK 

PROVIDER: S-EPMC4324078 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature