Rarity of the Alzheimer disease-protective APP A673T variant in the United States.

ABSTRACT:

Importance

Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position 673 (A673T), appears to protect against late-onset Alzheimer disease (AD). We evaluated the frequency of this variant in AD cases and cognitively normal controls to determine whether this variant will significantly contribute to risk assessment in individuals in the United States.

Objective

To determine the frequency of the APP A673T variant in a large group of elderly cognitively normal controls and AD cases from the United States and in 2 case-control cohorts from Sweden.

Design, setting, and participants

Case-control association analysis of variant APP A673T in US and Swedish

SUBMITTER: Wang LS 

PROVIDER: S-EPMC4324097 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature