A journey to uncharted territory: new technical frontiers in studying tumor-stromal cell interactions.

ABSTRACT: The crosstalk between tumor cells and cells of the tumor stroma dictate malignant progression and represent an intriguing and viable anticancer therapeutic target. The successful development of therapeutics targeting tumor-stroma interactions is tied to the insight provided by basic research on such crosstalk. Tumor-stroma interactions can be transient and dynamic, and they occur within defined spatiotemporal contexts among genetically and compositionally heterogeneous populations of cells, yet methods currently applied to study the said crosstalk do not sufficiently address these features. Emerging imaging and genetic methods, however, can overcome limitations of traditional approaches and provide unprecedented insight into tumor-stroma crosstalk with unparalleled accuracy. The comprehens

SUBMITTER: Guldner IH 

PROVIDER: S-EPMC4324098 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature