Integrating multi-omic features exploiting Chromosome Conformation Capture data.

ABSTRACT: The representation, integration, and interpretation of omic data is a complex task, in particular considering the huge amount of information that is daily produced in molecular biology laboratories all around the world. The reason is that sequencing data regarding expression profiles, methylation patterns, and chromatin domains is difficult to harmonize in a systems biology view, since genome browsers only allow coordinate-based representations, discarding functional clusters created by the spatial conformation of the DNA in the nucleus. In this context, recent progresses in high throughput molecular biology techniques and bioinformatics have provided insights into chromatin interactions on a larger scale and offer a formidable support for the interpretation of multi-omic data. In particul

SUBMITTER: Merelli I 

PROVIDER: S-EPMC4324155 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature