Cystatin C-based renal function changes after antiretroviral initiation: a substudy of a randomized trial.

ABSTRACT:

Background

The effects of antiretrovirals on cystatin C-based renal function estimates are unknown.

Methods

We analyzed changes in renal function using creatinine and cystatin C-based estimating equations in 269 patients in A5224s, a substudy of study A5202, in which treatment-naive patients were randomized to abacavir/lamivudine or tenofovir/emtricitabine with open-label atazanavir/ritonavir or efavirenz.

Results

Changes in renal function significantly improved (or declined less) with abacavir/lamivudine treatment compared with tenofovir/emtricitabine using the Cockcroft-Gault formula (P = .016) and 2009 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI; P = .030) and 2012 CKD-EPI cystatin C-creatinine (P = .025). Renal function changes significantly improve

SUBMITTER: Gupta SK 

PROVIDER: S-EPMC4324191 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature