Endothelial activation and repair during hantavirus infection: association with disease outcome.

ABSTRACT:

Background

Endothelial activation and dysfunction play a central role in the pathogenesis of sepsis and viral hemorrhagic fevers. Hantaviral disease is a viral hemorrhagic fever and is characterized by capillary dysfunction, although the underlying mechanisms for hantaviral disease are not fully elucidated.

Methods

The temporal course of endothelial activation and repair were analyzed during Puumala hantavirus infection and associated with disease outcome and a marker for hypoxia, insulin-like growth factor binding protein 1 (IGFBP-1). The following endothelial activation markers were studied: endothelial glycocalyx degradation (syndecan-1) and leukocyte adhesion molecules (soluble vascular cellular adhesion molecule 1, intercellular adhesion molecule 1, and endothelial sele

SUBMITTER: Connolly-Andersen AM 

PROVIDER: S-EPMC4324194 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature