Seasonal influenza vaccination is the strongest correlate of cross-reactive antibody responses in migratory bird handlers.

ABSTRACT:

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Avian species are reservoirs of influenza A viruses and could harbor viruses with significant pandemic potential. We examined the antibody and cellular immune responses to influenza A viruses in field or laboratory workers with a spectrum of occupational exposure to avian species for evidence of zoonotic infections. We measured the seroprevalence and T cell responses among 95 individuals with various types and degrees of prior field or laboratory occupational exposure to wild North American avian species using whole blood samples collected in 2010. Plasma samples were tested using endpoint enzyme-linked immunosorbent assay (ELISA) and hemagglutination (HA) inhibition (HAI) assays to subtypes H3, H4, H5, H6, H7, H8, and H12 proteins. Detectable antibodies were found again

SUBMITTER: Oshansky CM 

PROVIDER: S-EPMC4324241 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature