Candida albicans hypha formation and mannan masking of β-glucan inhibit macrophage phagosome maturation.

ABSTRACT:

Unlabelled

Candida albicans is a major life-threatening human fungal pathogen in the immunocompromised host. Host defense against systemic Candida infection relies heavily on the capacity of professional phagocytes of the innate immune system to ingest and destroy fungal cells. A number of pathogens, including C. albicans, have evolved mechanisms that attenuate the efficiency of phagosome-mediated inactivation, promoting their survival and replication within the host. Here we visualize host-pathogen interactions using live-cell imaging and show that viable, but not heat- or UV-killed C. albicans cells profoundly delay phagosome maturation in macrophage cell lines and primary macrophages. The ability of C. albicans to delay phagosome maturation is dependent on cell wall composition

SUBMITTER: Bain JM 

PROVIDER: S-EPMC4324242 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature