Malaria induces anemia through CD8+ T cell-dependent parasite clearance and erythrocyte removal in the spleen.

ABSTRACT:

Unlabelled

Severe malarial anemia (SMA) in semi-immune individuals eliminates both infected and uninfected erythrocytes and is a frequent fatal complication. It is proportional not to circulating parasitemia but total parasite mass (sequestered) in the organs. Thus, immune responses that clear parasites in organs may trigger changes leading to anemia. Here, we use an outbred-rat model where increasing parasite removal in the spleen escalated uninfected-erythrocyte removal. Splenic parasite clearance was associated with activated CD8(+) T cells, immunodepletion of which prevented parasite clearance. CD8(+) T cell repletion and concomitant reduction of the parasite load was associated with exacerbated (40 to 60%) hemoglobin loss and changes in properties of uninfected erythrocytes. T

SUBMITTER: Safeukui I 

PROVIDER: S-EPMC4324318 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature