Osteogenic potential of osteoblasts from neonatal rats born to mothers treated with caffeine throughout pregnancy.

ABSTRACT:

Background

Caffeine is an active alkaloid that can cause damage to bones in formation during prenatal life into adulthood. This compound can pass across the placenta and into the mother's milk, causing a reduction in bone formation, growth and mass. The objective of this study was to examine the osteogenic potential of osteoblasts extracted from neonatal rats born to mothers treated with caffeine throughout pregnancy.

Methods

Twenty-four adult Wistar rats were randomly divided into four groups, consisting of one control group and three groups that were treated with 25, 50, or 100 mg/kg of caffeine by an oral-gastric probe throughout the duration of the experimental period (pregnancy). At birth, three puppies from each dam in each group were euthanized, and osteoblasts were e

SUBMITTER: Reis AM 

PROVIDER: S-EPMC4324429 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature