A Subsequent Human Neural Progenitor Transplant into the Degenerate Retina Does Not Compromise Initial Graft Survival or Therapeutic Efficacy.

ABSTRACT:

Purpose

Stem and progenitor cell transplantation provides a promising clinical application for treating degenerative retinal diseases, including age-related macular degeneration (AMD) and retinitis pigmentosa (RP). Our previous studies have shown that a single subretinal injection of human cortical-derived neural progenitor cells (hNPC^ctx) into cyclosporine-treated Royal College of Surgeons (RCS) rats preserved both photoreceptors and visual function. However, it is still unknown whether nonautologous progenitor cell readministration for sustained vision is efficacious and safe in terms of the initial graft initiating an immune response to a subsequent graft.

Methods

A cell suspension containing 3×10⁴ hNPC^ctx into one eye of cyclosporine-trea

SUBMITTER: Lu B 

PROVIDER: S-EPMC4324446 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature