Efficacy and safety of pharmacological and psychological interventions for the treatment of psychosis and schizophrenia in children, adolescents and young adults: a systematic review and meta-analysis.

ABSTRACT:

Background

Studies report contrasting results regarding the efficacy and safety of pharmacological, psychological, and combined interventions in psychosis and schizophrenia in children, adolescents and young adults.

Methods

Systematic review and meta-analysis. Embase, Medline, PreMedline, PsycINFO, and CENTRAL were searched to July 2013 without restriction to publication status. Randomised trials comparing any pharmacological, psychological, or combined intervention for psychosis and schizophrenia in children, adolescents and young adults were included. Studies were assessed for bias, and GRADE criteria were used to describe the quality of the results.

Results

Twenty-seven trials including 3067 participants were identified. Meta-analyses were performed for 12 comparis

SUBMITTER: Stafford MR 

PROVIDER: S-EPMC4324833 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature