Ontology highlight
ABSTRACT:
SUBMITTER: Merkle FT
PROVIDER: S-EPMC4325380 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20150201 4
Hypothalamic neurons orchestrate many essential physiological and behavioral processes via secreted neuropeptides, and are relevant to human diseases such as obesity, narcolepsy and infertility. We report the differentiation of human pluripotent stem cells into many of the major types of neuropeptidergic hypothalamic neurons, including those producing pro-opiolemelanocortin, agouti-related peptide, hypocretin/orexin, melanin-concentrating hormone, oxytocin, arginine vasopressin, corticotropin-re ...[more]