A crowd-sourcing approach for the construction of species-specific cell signaling networks.

ABSTRACT:

Motivation

Animal models are important tools in drug discovery and for understanding human biology in general. However, many drugs that initially show promising results in rodents fail in later stages of clinical trials. Understanding the commonalities and differences between human and rat cell signaling networks can lead to better experimental designs, improved allocation of resources and ultimately better drugs.

Results

The sbv IMPROVER Species-Specific Network Inference challenge was designed to use the power of the crowds to build two species-specific cell signaling networks given phosphoproteomics, transcriptomics and cytokine data generated from NHBE and NRBE cells exposed to various stimuli. A common literature-inspired reference network with 220 nodes and 501 edges w

SUBMITTER: Bilal E 

PROVIDER: S-EPMC4325542 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature