Developing highER-throughput zebrafish screens for in-vivo CNS drug discovery.
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ABSTRACT:
SUBMITTER: Stewart AM
PROVIDER: S-EPMC4325915 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Developing highER-throughput zebrafish screens for in-vivo CNS drug discovery.
Stewart Adam Michael AM Gerlai Robert R Kalueff Allan V AV
Frontiers in behavioral neuroscience 20150212
The high prevalence of brain disorders and the lack of their efficient treatments necessitate improved in-vivo pre-clinical models and tests. The zebrafish (Danio rerio), a vertebrate species with high genetic and physiological homology to humans, is an excellent organism for innovative central nervous system (CNS) drug discovery and small molecule screening. Here, we outline new strategies for developing higher-throughput zebrafish screens to test neuroactive drugs and predict their pharmacolog ...[more]
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